CORONAVIRUS PANDEMIC UPDATE: ANOTHER HYDROXYCHLOROQUINE STUDY BOMBS

-
By Akin Ojumu

So, another hydroxychloroquine study bombs. Duh! Is anyone really surprised? 

This is yet another scientific nail in the coffin of the chloroquine is the “game changer" against COVID-19” quackery.

This is exactly why science matters. It is the reason there’s a gulf of difference between anecdotes and empirical data. And it goes to show that wishful thinking and false hope do not equate to scientific evidence or clinical efficacy.

STUDY TITLE: Hydroxychloroquine in Patients with COVID-19: an Open Label, Randomized, Controlled Trial

STUDY AUTHORS: Wei Tang, Zhujun Cao, Mingfeng Han et al

STUDY OBJECTIVES: To assess the efficacy and safety of hydroxychloroquine (HCQ) plus standard-of-care (SOC) compared with SOC alone in adult patients with COVID-19

STUDY DESIGN: Multicenter, Open label, randomized controlled trial

STUDY LOCATION: 16 government-designated COVID-19 treatment centers in China

STUDY PERIOD: February 11 to 29, 2020

STUDY PARTICIPANTS: 150 patients, 18 years or older, hospitalized with COVID-19

STUDY METHOD: 75 patients received standard-of-care, while another 75 received standard-of-care plus a loading dose of 1200 mg HCQ/day for the first three days, followed by 800 mg once daily for two weeks (or three weeks in severe cases)

PRIMARY ENDPOINT: Rate of negative swab tests at day 28

SECONDARY ENDPOINTS: Negative tests at the earlier time points, improvement rate of clinical symptoms within the 28 days, and normalization of C-reactive protein (CRP) and lymphocyte count within that same period

STUDY RESULT: The overall 28-day negative conversion rate was not different between standard-of-care plus HCQ and standard-of-care group. Negative conversion rate at day 4, 7, 10, 14 or 21 was also similar between the two groups. No different 28-day symptoms alleviation rate was observed between the two groups

CONCLUSIONS: No significant differences were seen with hydroxychloroquine treatment. There were no significant adverse events during the trial

https://www.medrxiv.org/content/10.1101/2020.04.10.20060558v1

Comments

Post a Comment

Popular posts from this blog

FACT CHECK: DID BOLA TINUBU CALL FOR REDUCTION OF NIGERIANS’ PURCHASING POWER?

-
Image
By Akin Ojumu  With respect to Bola Tinubu’s presidential aspiration, my position is pretty clear. Those who’ve been following my various commentaries on this issue know very well that I’m not a fan of Bola Tinubu and his unscrupulous campaign to become the next president of the Federal Republic of Nigeria.  My opposition to Bola Tinubu’s candidacy is visceral and intense. The man is a clear and present danger to the well-being of Nigeria, if he ever becomes president. BAT is an advanced metastatic cancer rapidly growing and spreading in the Nigeria polity. If the country must survive, this deadly cancer must be treated as all advanced cancers are treated; radical excision combined with several courses of radiotherapy and multiple cycles of chemotherapy cocktail in addition to the clearing of all associated lymph nodes. Now, there’s one thing I detest as much as Bola Tinubu’s presidential run, and that’s fake news. I cherish the truth, it’s the compass that guides us to safe shores. Wi
Read more

BECAUSE JOB DIDN’T TITHE, HIS LIFE BECAME TIGHT

-
Image
By Akin Ojumu Being the trust-but-verify guy that I am, while fact-checking a social media post by one of my High School friends, in which Bishop David Oyedepo was quoted to have linked the adversity of Job to his tithing habit, I was shocked, but not at all surprised, to find a 2019 video that did indeed confirm what my good friend shared.  In Bishop Oyedepo's telling, the real cause of Job's afflictions was his failure to pay tithes. According to him, God removed Job's divine security and allowed Satan to buffet him with calamity because the man was a habitual tithe defaulter. Because Job didn't tithe, his life became really tight. Here is the Bishop in his own words: “You can't see anywhere where Job tithed. So, his blessing was not secured. You can't find anywhere where Job tithed. No! He was overly committed to giving liberally to the poor and God was committed to bless him. But there was no security.” Just so it's absolutely clear. Bishop Oyedepo's
Read more

YOU CAN’T LOVE NIGERIA & WANT BOLA TINUBU AS ITS PRESIDENT

-
Image
By Akin Ojumu Asiwaju Bola Ahmed Tinubu is not a stranger to Nigerians. The man with the Graves Disease eyes has been around a long time. BAT is a vector of deadly viral disease of pandemic proportions. He is a parasite that takes over everything his hand touches.  The following is just a sample of what Bola Tinubu, allegedly, did to Lagos State: Number 4, Oyinkan Abayomi (Formerly Queens) Drive, Ikoyi – Valued at N450 Million A 5-bedroom detached house on one acre of land was Lagos State Governor’s guest house since 1979 Certificate of occupancy was signed and released to Tinubu by Fashola in 2007 26 Bourdillon Road, Ikoyi – Valued at N600 Million Originally claimed to be by Oando Plc Guest House, it was later acquired by Tinubu from Oando Lagos State Government paid to rebuild and renovate, it then purchased it from Tinubu for an undisclosed sum. Subsequently, the State handed the property back to Tinubu under the Pension Bill he signed into law shortly before Tinubu left office in 2
Read more